Table 4

Cytokine levels for various peptides in different haplotypes. Cytokine levels as measured for various peptide formulations in different haplotypes. The value represents the level of cytokines obtained from wells pulsed with the optimal antigen (peptides alone or in adjuvant systems) concentration which showed maximal T-cell stimulation index).
Strain→
 H-2 Haplotypes
 Cytokines (pg/ml)


Formulation↓
 BALB/c
(H-2d)
 CBA/J
(H-2k)
 C57BL/6J
(H-2b)
 FVB/J
(H-2q)
V3-gp41 Peptide
 611 ± 21
 311 ± 35
 727 ± 68
 878 ± 240
 IFN-γ

372 ± 90
 342 ± 28
 2322 ± 245
 260 ± 54
 IL-2

29 ± 3
 9.0 ± 1
 35 ± 3
 42 ± 6
 IL-4
V3-gp41 in Liposomes
 1076 ± 102
 855 ± 44
 1332 ± 221
 1854 ± 132
 IFN-γ

367 ± 35
 408 ± 36
 443 ± 24
 475 ± 25
 IL-2

19 ± 2
 8.0 ± 2
 40 ± 5
 7.0 ± 1
 IL-4
V3-gp41 in ISCOMs
 1956 ± 145
 2076 ± 126
 2178 ± 231
 2589 ± 321
 IFN-γ

665 ± 42
 757 ± 60
 667 ± 32
 660 ± 35
 IL-2

12 ± 1
 12 ± 2
 36 ± 5
 4.0 ± 1
 IL-4
V3-gp41: MA729 in Liposomes
 1856 ± 121
 2325 ± 231
 2560 ± 265
 2667 ± 320
 IFN-γ

821 ± 69
 754 ± 58
 702 ± 36
 753 ± 36
 IL-2

15 ± 5
 13 ± 3
 29 ± 5
 18 ± 5
 IL-4
gp41 Peptide
 520 ± 56
 655 ± 33
 765 ± 36
 333 ± 26
 IFN-γ

200 ± 12
 398 ± 25
 390 ± 25
 432 ± 20
 IL-2

53 ± 5
 32 ± 3
 57 ± 6
 41 ± 6
 IL-4
gp41 Peptide in Liposomes
 989 ± 65
 1177 ± 125
 1098 ± 89
 980 ± 66
 IFN-γ

445 ± 25
 506 ± 55
 535 ± 21
 582 ± 32
 IL-2

25 ± 6
 15 ± 3
 45 ± 5
 7.0 ± 1
 IL-4
gp41 Peptide in ISCOMs
 1884 ± 155
 1765 ± 211
 1678 ± 201
 2345 ± 315
 IFN-γ

700 ± 36
 814 ± 54
 721 ± 58
 765 ± 75
 IL-2

15 ± 4
 46 ± 5
 52 ± 6
 24 ± 3
 IL-4
gp41 : MA729 in Liposomes
 2577 ± 220
 2436 ± 233
 2245 ± 165
 2100 ± 103
 IFN-γ

789 ± 100
 676 ± 20
 723 ± 65
 703 ± 87
 IL-2

45 ± 6
 32 ± 5
 27 ± 8
 40 ± 5
 IL-4
p17 Peptide
 433 ± 21
 623 ± 12
 453 ± 52
 534 ± 31
 IFN-γ

360 ± 21
 183 ± 24
 243 ± 34
 253 ± 50
 IL-2

20 ± 6
 37 ± 3
 29 ± 8
 23 ± 6
 IL-4
p17 Peptide in Liposomes
 350 ± 30
 786 ± 35
 998 ± 53
 1052 ± 32
 IFN-γ

450 ± 27
 387 ± 26
 427 ± 32
 364 ± 32
 IL-2

30 ± 10
 20 ± 4
 51 ± 3
 45 ± 6
 IL-4
p17 Peptide in ISCOMs
 677 ± 59
 1321 ± 136
 1200 ± 70
 1400 ± 230
 IFN-γ

618 ± 60
 345 ± 32
 627 ± 51
 501 ± 34
 IL-2

23 ± 4
 23 ± 4
 12 ± 4
 57 ± 5
 IL-4
p17 : MA729 in Liposomes
 1756 ± 100
 1899 ± 120
 1500 ± 52
 1876 ± 320
 IFN-γ

489 ± 52
 665 ± 50
 603 ± 35
 581 ± 18
 IL-2

44 ± 13
 41 ± 10
 36 ± 5
 39 ± 6
 IL-4
p24 Peptide
 435 ± 23
 654 ± 36
 500 ± 35
 435 ± 35
 IFN-γ

354 ± 29
 385 ± 25
 256 ± 23
 334 ± 26
 IL-2

18 ± 5
 10 ± 2
 34 ± 5
 21 ± 8
 IL-4
p24 Peptide in Liposomes
 975 ± 63
 987 ± 54
 1123 ± 124
 786 ± 69
 IFN-γ

470 ± 56
 235 ± 19
 398 ± 54
 402 ± 30
 IL-2

29 ± 6
 30 ± 3
 22 ± 1
 32 ± 4
 IL-4
p24 Peptide in ISCOMs
 1352 ± 69
 1354 ± 54
 1245 ± 103
 1532 ± 301
 IFN-γ

665 ± 80
 478 ± 22
 444 ± 31
 676 ± 88
 IL-2

13 ± 5
 8.0 ± 6
 19 ± 4
 28 ± 4
 IL-4
p24 : MA729 in Liposomes
 1543 ± 56
 1763 ± 240
 1324 ± 99
 1432 ± 26
 IFN-γ

556 ± 40
 600 ± 56
 655 ± 87
 543 ± 45
 IL-2

23 ± 6
 27 ± 4
 38 ± 8
 21 ± 7
 IL-4

The value represents the level of cytokines obtained from wells pulsed with the optimal antigen (peptides alone or in adjuvant systems) concentration which showed maximal T-cell stimulation index.

Agrawal et al. Journal of Immune Based Therapies and Vaccines 2003 1:5   doi:10.1186/1476-8518-1-5
Open Data