Table 1

Human anti-anthrax PA83 antibody classification. The immunoglobulin sequence derived from the cDNA encoding the variable regions were used to search Vbase and the VH class, VH locus, DH and JH segments were assigned for the VH regions. Likewise VL class, VL locus and JL segments were assigned for the VL regions. Comparing the actual sequences and closest matched V family members the extent of somatic hyper mutation could be ascertained.
	VH					V L

Designation	VH Class	VH Locus	# Mutations from germline	DH(RF)	JH	VL Class	VL Locus	# Mutations from Germline	JL

AVP-21D9	VH3	3–43	26	6–19(1)	JH4b	VKI	L12	14	JK1
AVP-1C6	VH3	3–73	8	6–13(1)	JH3b/a	VKI	L18	13	JK4
AVP-4H7	VH4	4–39	29	unknown	JH6b/a	VL3	3h	22	JL2/JL3a
AVP-22G12	VH3	3–11	20	unknown	JH5b	VL3	3r	9	JL2/JL3a

Sawada-Hirai et al. Journal of Immune Based Therapies and Vaccines 2004 2:5 doi:10.1186/1476-8518-2-5