Table 1 |
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|
Protease Profiles Expressed by Several DC Populations |
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| Protease |
XS52 DC |
Splenic DC |
Bone Marrow DC |
BW5147 Thymoma Cells |
|
|
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| Cathepsin B1 |
133 ± 392 |
123 ± 3.3 |
121 ± 3.3 |
1.5 ± 0.08 |
| Cathepsin C |
34 ± 7 |
16 ± 4 |
0.4 ± 0.1 |
<0.01 |
| Cathepsin D/E |
34 ± 6 |
30 ± 14 |
22 ± 2 |
1.6 ± 0.1 |
| Cathepsin H |
2.8 ± 0.8 |
3.5 ± 0.7 |
1 ± 0.2 |
0.9 ± 0.2 |
| Cathepsin J |
26 ± 0.3 |
0.7 ± 0.3 |
3.0 ± 0.1 |
0.2 ± 0.09 |
| Cathepsin L |
14 ± 0.6 |
26 ± 11 |
19 ± 0.6 |
0.6 ± 0.08 |
| BLT esterase |
25,000 ± 400 |
58,000 ± 4,000 |
21,300 ± 100 |
<100 |
| Suc-FLF-SBz esterase |
1,900,000 ± 61,000 |
310,000 ± 10,800 |
1,150,000 ± 10,200 |
12,000 ± 100 |
| Suc-AAPFSBZ esterase |
433,000 ± 2,900 |
134,000 ± 7,300 |
360,000 ± 6,100 |
3,400 ± 600 |
|
|
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|
1Extracts prepared from the indicated cell types were examined for protease activities using a panel of standard substrates. 2Enzymatic activities are expressed as nmol/min/mg soluble protein. Data shown represent the mean ± SD from three independent preparations. |
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|
Mohamadzadeh et al. Journal of Immune Based Therapies and Vaccines 2004 2:8 doi:10.1186/1476-8518-2-8 |
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