|
Fold difference in geometric mean titers of VLP+MAA-immunized group over VLP alone-immunized group. |
||||||||||||
| A. |
HPV cLIA time (weeks) |
|||||||||||
| HPV type |
0 |
2 |
4 |
8 |
10 |
12 |
16 |
20 |
24 |
26 |
28 |
52 |
|
|
||||||||||||
| HPV 6 |
1.1 |
3.2 |
2.4 |
4.3 |
10.0 |
12.6 |
36.3 |
10.9 |
6.3 |
22.7 |
41.9 |
4.3 |
| HPV 11 |
0.8 |
2.9 |
2.2 |
5.5 |
23.5 |
18.1 |
16.2 |
8.2 |
6.1 |
18.4 |
36.8 |
5.3 |
| HPV 16 |
1.0 |
5.2 |
8.8 |
8.4 |
21.4 |
15.7 |
16.1 |
11.4 |
17.7 |
4.8 |
12.7 |
6.4 |
| HPV 18 |
1.0 |
4.8 |
13.7 |
19.4 |
70.5 |
18.6 |
27.1 |
35.4 |
26.3 |
6.7 |
26.8 |
26.7 |
|
|
||||||||||||
| B. |
HPV Total IgG antibodies time (weeks) |
|||||||||||
| HPV type |
0 |
2 |
4 |
8 |
10 |
12 |
16 |
20 |
24 |
26 |
28 |
52 |
|
|
||||||||||||
| HPV 6 |
1.9 |
9.5 |
9.5 |
13.1 |
125.0 |
328.3 |
125.0 |
65.7 |
34.4 |
34.5 |
65.7 |
18.1 |
| HPV 11 |
1.9 |
13.1 |
25.0 |
25.0 |
125.0 |
90.6 |
125.0 |
47.6 |
34.5 |
34.5 |
90.6 |
18.1 |
| HPV 16 |
0.9 |
5.0 |
9.5 |
6.9 |
65.7 |
65.7 |
90.6 |
65.7 |
13.1 |
13.1 |
65.7 |
25.0 |
| HPV 18 |
0.7 |
9.5 |
13.1 |
25.0 |
125.0 |
47.6 |
65.7 |
65.7 |
25.0 |
47.6 |
125.0 |
90.6 |
Ruiz et al. Journal of Immune Based Therapies and Vaccines 2005 3:2 doi:10.1186/1476-8518-3-2 |
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