  ReviewPsoriatic arthritis: Pathogenesis and novel immunomodulatory approaches to treatmentSarah Cassell  and Arthur Kavanaugh  Center for Innovative Therapy, Division of Rheumatology, Allergy, and Immunology, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0943, USA  author email corresponding author email
Journal of Immune Based Therapies and Vaccines 2005,
3:6doi:10.1186/1476-8518-3-6
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| Published: |
2 September 2005 |
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis. PsA runs a variable course, from mild synovitis to severe, progressive, erosive arthropathy. The pathogenesis of PsA involves alteration in the components of the immune response, although the exact cause of PsA is unknown. A number of patients with severe peripheral arthritis fail to respond to standard conventional therapy. Advances in biotechnology and in our understanding of the immunopathogenesis of PsA have led to great interest and progress in regards to biologic treatments for PsA. Notable success achieved with recently introduced biologic therapies has paved the way for further research and develpoment of additional therapies that should improve outcomes for affected patients. | 
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