|
Neutralizing antibody titer (NT titer) (geometric mean) of sera from immunized mice against heterologous H5N1 influenza virus (A/Thailand/1/RPNP/2005). Sera from 5 groups of 5 mice per recombinant protein immunization were collected 1 week after last immunization with 250 μg of recombinant HA or NA, or NS1 or M proteins. Mann-Whitney method |
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| Recombinant proteins |
Neutralization titer |
ELISA titer |
||
|
|
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| GMT (± SD) |
P |
GMT (± SD) |
P |
|
|
|
||||
| NA/COS-7 |
34 (± 8) |
0.36 |
160 (± 78) |
0.01 |
| NA/E. coli |
13 (± 5) |
60 (± 21) |
||
| HA/COS-7 |
91.8 (± 35.7) |
0.01 |
422 (± 175) |
0.28 |
| HA/E. coli |
22 (± 8) |
160 (± 87) |
||
| NS1/COS-7 |
139* (± 35) |
0.01 |
1688* (± 701) |
0.01 |
| NS1/E. coli |
22 (± 8) |
422 (± 175) |
||
| M/COS-7 |
0 |
NA |
40 (± 21) |
0.1 |
| M/E. coli |
0 |
22 (± 8) |
||
|
*Significant (P < 0.05, Mann-Whitney method, NS/COS-7 and other proteins) | ||||
Horthongkham et al. Journal of Immune Based Therapies and Vaccines 2007 5:10 doi:10.1186/1476-8518-5-10 |
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