Table 3

HBsAg antibody responses
Subject
 W0
 W8
 W12
 Subject
 W0
 W8
 W12
Engerix® -B


HBsAg + IMP321 10 μg


003
 0
 178
 2253
 013
 0
 0
 1
008
 0
 2589
 7055
 015
 0
 0
 4
014
 0
 0
 54
 017
 0
 0
 0
023
 0
 4
 442
 018
 0
 2
 28
026
 0
 3054
 3156
 019
 9
 504
 609
032
 0
 0
 28
 020
 0
 0
 0
040
 0
 9
 164
 1021
 0
 0
 0
043
 0
 2
 17
 022
 0
 0
 0
# Seroconverteda
 0
 6 (75%)
 8 (100%)
 # Seroconverteda
 0
 1 (14.2%)
 3 (42.8%)
# Seroprotecteda
 0
 3 (37.5%)
 8 (100%)
 # Seroprotecteda
 0
 0
 1 (14.2%)
GMTa, b
 1
 23.75
 313.56
 GMTa, b
 1
 1.10
 1.96
HBsAg alone


HBsAg + IMP321 30 μg


006
 0
 0
 0
 025
 0
 0
 0
012
 0
 0
 0
 027
 0
 0
 0
016
 0
 0
 0
 029
 0
 0
 0
024
 0
 0
 0
 030
 0
 0
 26
028
 0
 0
 7
 031
 0
 0
 0
034
 0
 0
 0
 033
 0
 0
 4
039
 0
 0
 2
 035
 2
 136
 467
044
 1
 24
 321
 036
 0
 0
 0
# Seroconverteda
 0
 0
 2 (28.5%)
 # Seroconverteda
 0
 0
 2 (28.5%)
# Seroprotecteda
 0
 0
 0
 # Seroprotecteda
 0
 0
 1 (14.2%)
GMTa, b
 1
 1
 1.46
 GMTa, b
 1
 1
 1.94
HBsAg + IMP321 3 μg


HBsAg + IMP321 100 μg


001
 0
 540
 2229
 037
 0
 0
 3
002
 0
 35
 51
 038
 0
 0
 3
004
 0
 0
 0
 041
 0
 0
 0
005
 0
 0
 0
 042
 0
 0
 0
007
 0
 0
 1
 045
 0
 0
 0
009
 0
 0
 12
 046
 0
 0
 0
1010
 0
 0
 1
 047
 0
 0
 0
011
 0
 0
 5
 048
 0
 0
 0
# Seroconverteda
 0
 2 (25%)
 6 (75%)
 # Seroconverteda
 0
 0
 2 (25%)
# Seroprotecteda
 0
 2 (25%)
 3 (37.5%)
 # Seroprotecteda
 0
 0
 0
GMTa, b
 1
 3.42
 7.15
 GMTa, b
 1
 1
 1.31

Protective titres are indicated in bold

a GMT, seroconversion and seroprotection calculations were based on naïve subjects only.

b Value of zero are assigned the value of 1 for the GMT calculation.

Brignone et al. Journal of Immune Based Therapies and Vaccines 2007 5:5   doi:10.1186/1476-8518-5-5