Table 1

Robust serum antibody response to simultaneous intradermal vaccination




Antibody concentration (μg/ml) mean ± SD








Vaccine




Isotype
 Day
 Treatment
BoNT/A(H c)
 rF1-V
 rPA
 STEBVax
IgM
 70
 Control
 (n = 8)
 3.07+/-0.87
 2.99+/-1.47
 6.31+/-3.16
 4.76+/-3.62

70
 Vaccinated
 (n = 24)
 5.47+/-2.20
 11.2+/-4.04
 13.7+/-9.28
 9.07+/-2.74


p-value*
0.0001
 < 0.0001
 0.002
 0.012
IgG
 14
 Control
 (n = 8)
 0.31+/-0.15
 2.1+/-3.1
 0.31+/-0.12
 1.25+/-1.76

14
 Vaccinated
 (n = 24)
 1.4+/-1.1
 421+/-196
 86+/-46
 121+/-109


p-value
< 0.0001
 < 0.0001
 < 0.0001
 < 0.0001


42
 Control
 (n = 8)
 0.28+/-0.22
 1.95+/-0.98
 2.2+/-1.4
 1.23+/-0.91

42
 Vaccinated
 (n = 24)
 4+/-2.1
 767+/-382
 689+/-397
 323+/-187


p-value
< 0.0001
 < 0.0001
 < 0.0001
 < 0.0001


70
 Control
 (n = 8)
 0.65+/-0.37
 1.05+/-1.08
 0.91+/-0.44
 1.93+/-1.25

70
 Vaccinated
 (n = 24)
 48+/-13
 2331+/-303
 2245+/-1224
 1340+/-215


p-value
< 0.0001
 < 0.0001
 < 0.0001
 < 0.0001

*Significance of mean serum IgM and IgG concentrations for control and vaccinated animals were compared using Student's t-test.

Morefield et al. Journal of Immune Based Therapies and Vaccines 2008 6:5   doi:10.1186/1476-8518-6-5

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