Cytokine production in STZ injected mice previously vaccinated with DNA-HSP65. TNF-α (A) and IL-10 (B) were assessed by ELISA in spleen cell cultures stimulated with recombinant Hsp65 and concanavalin A. Statistical significance was determined by ANOVA followed by Tukey's test. *p < 0.05 versus control group and #p < 0.05 versus STZ group.
Santos et al. Journal of Immune Based Therapies and Vaccines 2009 7:4 doi:10.1186/1476-8518-7-4