CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis

doi:10.1186/1476-8518-8-1

Journal of Immune Based Therapies and Vaccines

Volume 8

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Bhagawati-Prasad VN
De Leenheer E
Keefe NP
Ryan LA
Carlring J
Heath AW

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De Leenheer E
Keefe NP
Ryan LA
Carlring J
Heath AW
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CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis

Vijay NS Bhagawati-Prasad¹^* , Evy De Leenheer¹^* , Nadine P Keefe¹ , Lorna A Ryan¹ , Jennifer Carlring¹ and Andrew W Heath¹^,2

¹Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK

²Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK

author email corresponding author email* Contributed equally

Journal of Immune Based Therapies and Vaccines 2010, 8:1doi:10.1186/1476-8518-8-1


Published:	4 February 2010

Abstract

Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A™.