Short report
CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis
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* Corresponding author: Andrew W Heath a.w.heath@shef.ac.uk
- † Equal contributors
1 Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK
2 Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK
Journal of Immune Based Therapies and Vaccines 2010, 8:1 doi:10.1186/1476-8518-8-1
Published: 4 February 2010Abstract
Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A™.