Table 3

Production effects (Paratuberculosis clinical cases or mortality rates).

Vaccine

Country and reference

Year

Number of animals

Age at vaccination

Reduction

(%)

Type of trial


Name/Laboratory

Type

Strain/Antigen

Adjuvant


Cattle


NCV

Live

6 strains

Oil

U.S.A. [65]

1935

20

1 m

100,00

E, MC, CC

Weybridge

Live

316F

P/O/P

U.K. [66]

1959

63401

1 m

93.45

F, IF, CC

Weybridge

Live

316F

P/O/P

U.K. [67]

1964

2440

1 m

98.36

F, IF, CC

Weybridge

Live

316F

P/O/P

U.K. [68]

1965

84

1 w

46.67

E, MC, CC

Weybridge

Live

316F

P/O/P

U.K. [69]

1982

150000

1 m

99.06

F, IF, CC

Fromm

Killed

M.a.a strain 18

Oil

U.S.A. [70]

1983

48

1 m

35.29

F, MC, CC

-

Live

316F

P/O/P

France [61]

1988

902

1 m

87.34

F, IF, CC

-

Live

316F

P/O/P

France [61]

1988

1037

1 m

97.22

F, IF, CC

Lelystad

Killed

-

Oil

Netherlands [59]

1988

851

1-24 m

87.05

F, IF, CC

Lelystad

Killed

-

Oil

Netherlands [71]

1992

61050

1 m

91.82

F, MC, CC

NCV

Killed

-

Oil

Netherlands [72]

1994

337

1 m

79.01

F, IF, CC

NCV

Killed

-

Oil

Netherlands [37]

1996

573

1 m

68.14

F, CC


Average

96.02 ± 0.01


Sheep


NCV

Live

316F

Oil Paraffin

Greece [73]

1988

1448

1 m

76.14

F, MC, TM

NCV

Live

316F

Oil Paraffin

Greece [73]

1988

5526

Adults

28.74

F, MC, TM

Lio-Johne

Live

316F

Oil

Spain [74]

1993

1201

Adults

78.29

F, MC, CC

Lio-Johne

Live

316F

Oil

Spain [75]

1995

570

1 m

52.55

F, MC, TM

Weybridge

Live

316F

P/O/P

U.K. [76]

1993

830

Adults

89.86

F, IF, CC

Neoparasec & NCV

Live & Killed

316F

-

Oil

Oil

Spain [77]

1995

857

Adults

54.55

F, IF, CC

Neoparasec

Live

316F

Oil

New Zealand [78]

2000

28

1-1.5 m

71.43

E, MC, CC

Gudair

Killed

316F

Oil

Australia [79]

2003

8000

3, 8 m, 2 y

87.50

F, IF, mort rate

Gudair

Killed

316F

Oil

Australia [80]

2004

1200

1-4 m

90.00

F,MC, mort reduction

Gudair

Killed

316F

Oil

Australia [34]

2006

400

1-3 m

91.25

F, MC, TM

Gudair

Killed

316F

Oil

New Zealand [81]

2009

65

4 m

78.57

E, MC, CA

NCV

Killed

316F

Lipid-K formulation

New Zealand [81]

2009

65

4 m

57.14

E, MC, CA

NCV

Live

316F

Lipid-K formulation

New Zealand [81]

2009

65

4 m

14.29

E, MC, CA

NCV

Live

316F

Lipid-K formulation

New Zealand [81]

2009

65

4 m

35.71

E, MC, CA


Average

67.57% ± 0.35


Goats


NCV

Live

316F

Oil Paraffin

Greece [73]

1988

2178

1 m

82.78

F, MC, TM

NCV

Live

316F

Oil Paraffin

Greece [73]

1988

7773

Adults

34.52

F, MC, TM


Average

45.08 ± 0.39


NCV: non-commercial vaccine; Weybridge: Central Veterinary Laboratory, Weybridge, UK; Fromm: Fromm Laboratories, Grafton, Wisconsin USA; Lelystad: Central Veterinary Institute, Lelystad, The Netherlands; Lio-Johne, Ovejero, Spain; Neoparasec: Neoparasec®, Merial; Gudair: Gudair®, CZ Veterinaria/Pfizer; P/O/P Paraffin, Olive Oil, Pumice Stone Powder; y: year(s); m: month(s); w: week(s); d: day(s); F: Field trial; E: Experimental infection; MC: Comparison to matched controls; IF: Comparison of initial versus final prevalence; TM: Total mortality; CC: clinical cases; NVH: Comparison to non-vaccinating herds.

Bastida and Juste Journal of Immune Based Therapies and Vaccines 2011 9:8   doi:10.1186/1476-8518-9-8

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