Table 5

Pathogenetic effects (histopathological lesions).

Vaccine

Country and reference

Year

Number of animals

Age at vaccination

Reduction (%)

Type of trial


Name/Laboratory

Type

Strain/Antigen

Adjuvant


Cattle


NCV

Live

6 strains

Oil

U.S.A. [65]

1935

20

calves

42.86

E, HP

NCV

Live

avirulent

P/O/P

U.S.A. [83]

1974

16

16 d

17.24

E, HP

Lelystad

Killed

-

None

Netherlands [71]

1992

3209

1 m

58.34

F, IF, HP

NCV

Killed

-

Oil

Netherlands [72]

1994

499

1 m

57.23

F, IF, HP

NCV

Killed

-

Oil

Netherlands [37]

1996

573

1 m

58.09

F, IF, HP

Silirum

Killed

316F

Oil

Spain [103]

2005

79

all ages

38.68

F, MC, HP

Silirum

Killed

316F

Oil

Spain [90]

2005

14

2 m

37.50

E, MC, HP


Average

57.54 ± 0.11


Sheep


NCV

Killed

-

Oil

Iceland [54]

1960

419

3 m

83.58

F, MC, PM

NCV

Killed

-

Oil

Iceland [54]

1960

24323

3 m

93.55

F, MC, PM

NCV

Killed

Oil

U.K. [95]

1962

126

1 m

52.22

E, MC, HP

Lio-Johne

Live

316F

Oil

Spain [74]

1993

570

1 m

100.00

F, MC, HP

Lio-Johne

Live

316F

Oil

Spain [74]

1993

1201

Adults

53.36

F, MC, HP

Neoparasec

Live

316F

Oil

Spain [96]

1994

13

2 m

64.52

E, MC, HP

Neoparasec

Live

316F

Oil

Australia [104]

1995

475

3 m

82.27

F, MC. HP

Neoparasec & Gudair

Live and Killed

316F

Oil

Spain [77]

1995

135

Adults

-3.03

F, IF, HP,

Neoparasec

Live

316F

Oil

New Zealand [78]

2000

28

1-1.5 m

77.78

E, MC, HP

Gudair

Killed

316F

Oil

Spain [105]

2002

12

1 m

100.00

E, MC, HP

Mycopar

Killed

M.a.a.

Strain 18

Oil

U.S.A. [106]

2005

178

60-164 d

75.31

F, MC, HP

Neoparasec

Live

316F

Oil

New Zealand [57]

2005

59

2-4 w

68.52

E, MC, HP

AquaVax

Live

316F

saline

New Zealand [57]

2005

58

2-4 w

-2.48

E, MC, HP

Gudair

Killed

316F

Oil

Australia [34]

2006

88

1-3 m

72.70

F, MC, GL, HP

Gudair

Killed

316F

Oil

Australia [34]

2006

307

1-3 m

48.29

F, MC, GL, HP

Gudair

Killed

316F

Oil

New Zealand [81]

2009

62

4 m

75.57

E, MC, HP

NCV

Killed

316F

Lipid-K formulation

New Zealand [81]

2009

63

4 m

37.17

E, MC, HP

NCV

Live

316F

Lipid-K formulation

New Zealand [81]

2009

63

4 m

51.32

E, MC, HP

NCV

Live

316F

Lipid-K formulation

New Zealand [81]

2009

62

4 m

57.56

E, MC, HP


Average

89.70 ± 0.15


Goats


NCV

Live

2E/316F

P/O/P

Norway [26]

1985

5535

1 m

97.18

F, IF, PM

Gudair

Killed

316F

Oil

Spain [38]

2000

189

Adults

65.88

F, MC, HP

NCV

Killed

Goat isolate (CWD)

QS21

U.S.A. [102]

2007

20

1 w

34.38

E, MC, HP

NCV

Killed

Goat isolate (CWC)

QS21

U.S.A. [102]

2007

20

1 w

32.03

E, MC, HP

NCV

Killed

Goat isolate (CWC)

Alum

U.S.A. [102]

2007

20

1 w

44.53

E, MC, HP

NCV

Killed

Goat isolate (CWD)

Alum

U.S.A. [102]

2007

20

1 w

-17.19

E, MC, HP

NCV

Killed

Virulent Field Strain

Alum

India [48]

2007

8

4-6 m

75.00

E, MC, HP

Gudair

Killed

316F

Oil

India [48]

2007

8

4-6 m

50.00

E, MC, HP

NCV

Rec

MAP(85A, 85B, SOD, 74F)

DDA

U.S.A. [40]

2009

17

5-10 d

66.67

E, MC, HP

NCV

Rec

MAP(85A, 85B, SOD, 74F)

none

U.S.A. [40]

2009

17

5-10 d

33.33

E, MC, HP


Average

94.79% ± 0.29


NCV: non-commercial vaccine; Lelystad: Central Veterinary Institute, Lelystad, The Netherlands; Silirum: Silirum®, CZ Veterinaria/Pfizer; Lio-Johne, Ovejero, Spain; Neoparasec: Neoparasec®, Merial; Gudair: Gudair®, CZ Veterinaria/Pfizer; Mycopar®: Mycopar Fort Doge/Solvay, USA; AquaVax; Rec: recombinant; CWD Cell Wall Deficient MAP; CWC Cell Wall Competent MAP; P/O/P Paraffin, Olive Oil, Pumice Stone Powder; y: year(s); m: month(s); w: week(s); d: day(s); F: Field trial; E: Experimental infection; MC: Comparison to matched controls; IF: Comparison of initial versus final prevalence; GL: Gross lesions; HL: Histological lesions.

Bastida and Juste Journal of Immune Based Therapies and Vaccines 2011 9:8   doi:10.1186/1476-8518-9-8

Open Data